Cytokine receptor signalling and aging

T Fulop, A Larbi, N Douziech, I Levesque… - Mechanisms of Ageing …, 2006 - Elsevier
With ageing the immune system is deregulated and this leads to the development of
immunosenescence mainly affecting the adaptive immune response. There is much
knowledge accumulated concerning various receptor functions and signalling with ageing
such as TCR, FcRs, TLRs. Cytokines are playing a major role in haematopoietic cell
functions and in the harmonious and integrated coordination of the innate and adaptive
immune response. There exists a large amount of data on cytokine production changes with …