[HTML][HTML] Structural and functional attributes of the interleukin-36 receptor
G Yi, JA Ybe, SS Saha, G Caviness, E Raymond… - Journal of Biological …, 2016 - ASBMB
Signal transduction by the IL-36 receptor (IL-36R) is linked to several human diseases.
However, the structure and function of the IL-36R is not well understood. A molecular model
of the IL-36R complex was generated and a cell-based reporter assay was established to
assess the signal transduction of recombinant subunits of the IL-36R. Mutational analyses
and functional assays have identified residues of the receptor subunit IL-1Rrp2 needed for
cytokine recognition, stable protein expression, disulfide bond formation and glycosylation …
However, the structure and function of the IL-36R is not well understood. A molecular model
of the IL-36R complex was generated and a cell-based reporter assay was established to
assess the signal transduction of recombinant subunits of the IL-36R. Mutational analyses
and functional assays have identified residues of the receptor subunit IL-1Rrp2 needed for
cytokine recognition, stable protein expression, disulfide bond formation and glycosylation …