The novel interleukin-1 cytokine family members in inflammatory diseases
M Hahn, S Frey, AJ Hueber - Current opinion in rheumatology, 2017 - journals.lww.com
M Hahn, S Frey, AJ Hueber
Current opinion in rheumatology, 2017•journals.lww.comSummary IL-36, IL-37, and IL-38 are involved in the pathogenesis of the inflammatory
diseases psoriasis, rheumatoid arthritis, gout, systemic lupus erythematosus as well as
Crohn's disease. Thereby IL-36 acts proinflammatory triggering further inflammatory
mediators. In contrast, IL-37 and IL-38 are upregulated to counteract. Understanding the
imbalance of the IL-1 family is crucial for future therapeutics.
diseases psoriasis, rheumatoid arthritis, gout, systemic lupus erythematosus as well as
Crohn's disease. Thereby IL-36 acts proinflammatory triggering further inflammatory
mediators. In contrast, IL-37 and IL-38 are upregulated to counteract. Understanding the
imbalance of the IL-1 family is crucial for future therapeutics.
Summary
IL-36, IL-37, and IL-38 are involved in the pathogenesis of the inflammatory diseases psoriasis, rheumatoid arthritis, gout, systemic lupus erythematosus as well as Crohn's disease. Thereby IL-36 acts proinflammatory triggering further inflammatory mediators. In contrast, IL-37 and IL-38 are upregulated to counteract. Understanding the imbalance of the IL-1 family is crucial for future therapeutics.
Lippincott Williams & Wilkins