Tackling epilepsy with high-definition precision medicine: a review

H Kearney, S Byrne, GL Cavalleri, N Delanty - JAMA neurology, 2019 - jamanetwork.com
Importance Various types of epilepsy are a leading cause of neurological disability
worldwide; they have in common a propensity to recurrent unprovoked seizures. There is
increasing interest in the concept of precision medicine for therapy. While treatment aimed at
the level of an ion channel or single pathway has provided benefits for a small number of
individuals with genetically mediated cases, a high-definition approach extending beyond
genes to a broader array of personalized factors may improve outcomes. Observations …