Mitochondrial dysfunction may play a role in the pathogenesis of several renal diseases.
Although functional roles and metabolic demands differ among tubule segments, relatively
little is known about the properties of mitochondria in different parts of the nephron.
Clinically, the proximal tubule seems particularly vulnerable to mitochondrial toxicity. In this
study, we used multiphoton imaging of live rat kidney slices to investigate differences in
mitochondrial function along the nephron. The mitochondrial membrane potential was …