Use of a highly purified α1-antitrypsin standard to establish ranges for the common normal and deficient α1-antitrypsin phenotypes
ML Brantly, JT Wittes, CF Vogelmeier, RC Hubbard… - Chest, 1991 - Elsevier
Diagnosis of the hereditary disorder α 1-antitrypsin (α 1 AT) deficiency is critically dependent
on quantification of serum levels of α 1 AT, a 52-kDa antiprotease that serves to protect the
lung from destruction by neutrophil elastase. Although the measurement of serum α 1 AT
levels is not difficult, there is no international standard for α 1 AT, and investigators in the
field recognize that widely used commercially available standards vary by as much as 50
percent. To establish accurate ranges for the common normal and deficient α 1 AT …
on quantification of serum levels of α 1 AT, a 52-kDa antiprotease that serves to protect the
lung from destruction by neutrophil elastase. Although the measurement of serum α 1 AT
levels is not difficult, there is no international standard for α 1 AT, and investigators in the
field recognize that widely used commercially available standards vary by as much as 50
percent. To establish accurate ranges for the common normal and deficient α 1 AT …