Detection of increased intracerebral lactate in a mouse model of Leigh syndrome using proton MR spectroscopy

Y Takahashi, H Kioka, Y Shintani, A Ohki… - Magnetic Resonance …, 2019 - Elsevier
Purpose To establish a brain proton magnetic resonance spectroscopy (1 H MRS)
experimental system using a mouse model of Leigh syndrome for monitoring intracerebral
lactate levels as a biomarker of mitochondrial disease progression. Materials and methods
Brain 1 H MRS was performed in the Ndufs4 homozygous knockout (KO) mice, a mouse
model of Leigh syndrome, and control mice on a horizontal 7.0-T magnetic resonance
imaging system at age 5–9 weeks. In a subset of KO mice, survival analysis was performed …