Intratumoral immunotherapy of established solid tumors with chitosan/IL-12

DA Zaharoff, KW Hance, CJ Rogers… - Journal of …, 2010 - journals.lww.com
IL-12 is a potent antitumor cytokine that exhibits significant clinical toxicities after systemic
administration. We hypothesized that intratumoral (it) administration of IL-12 coformulated
with the biodegradable polysaccharide chitosan could enhance the antitumor activity of IL-
12 while limiting its systemic toxicity. Noninvasive imaging studies monitored local retention
of IL-12, with and without chitosan coformulation, after it injection. Antitumor efficacy of IL-12
alone and IL-12 coformulated with chitosan (chitosan/IL-12) was assessed in mice bearing …