[HTML][HTML] DAP12-mediated signal transduction in natural killer cells: a dominant role for the Syk protein-tyrosine kinase
DW McVicar, LS Taylor, P Gosselin… - Journal of Biological …, 1998 - ASBMB
The murine Ly49 family contains nine genes in two subgroups: the inhibitory receptors
(Ly49A, B, C, E, F, G2, and I) and the noninhibitory receptors (Ly49D and H). Unlike their
inhibitory counterparts, Ly49D and H do not contain immunoreceptor tyrosine-based
inhibitory motifs but associate with a recently described co-receptor, DAP12, to transmit
positive signals to natural killer (NK) cells. DAP12 is also expressed in myeloid cells, but the
receptors coupled to it there are unknown. Here we document the signaling pathways of the …
(Ly49A, B, C, E, F, G2, and I) and the noninhibitory receptors (Ly49D and H). Unlike their
inhibitory counterparts, Ly49D and H do not contain immunoreceptor tyrosine-based
inhibitory motifs but associate with a recently described co-receptor, DAP12, to transmit
positive signals to natural killer (NK) cells. DAP12 is also expressed in myeloid cells, but the
receptors coupled to it there are unknown. Here we document the signaling pathways of the …