Alveolar macrophage phagocytosis and bacteria clearance in mice

N Nagre, X Cong, AC Pearson, X Zhao - JoVE (Journal of Visualized …, 2019 - jove.com
Alveolar macrophages (AMs) guard the alveolar space of the lung. Phagocytosis by AMs
plays a critical role in the defense against invading pathogens, the removal of dead cells or
foreign particles, and in the resolution of inflammatory responses and tissue remodeling,
processes that are mediated by various surface receptors of the AMs. Here, we report
methods for the analysis of the phagocytic function of AMs using in vitro and in vivo assays
and experimental strategies to differentiate between the pattern recognition receptor …