[HTML][HTML] Lung CD4+ resident memory T cells remodel epithelial responses to accelerate neutrophil recruitment during pneumonia
Previous pneumococcal experience establishes lung-resident IL-17A-producing CD4+
memory T RM cells that accelerate neutrophil recruitment against heterotypic pneumococci.
Herein, we unravel a novel crosstalk between CD4+ T RM cells and lung epithelial cells
underlying this protective immunity. Depletion of CD4+ cells in pneumococcus-experienced
mice diminished CXCL5 (but not CXCL1 or CXCL2) and downstream neutrophil
accumulation in the lungs. Epithelial cells from experienced lungs exhibited elevated mRNA …
memory T RM cells that accelerate neutrophil recruitment against heterotypic pneumococci.
Herein, we unravel a novel crosstalk between CD4+ T RM cells and lung epithelial cells
underlying this protective immunity. Depletion of CD4+ cells in pneumococcus-experienced
mice diminished CXCL5 (but not CXCL1 or CXCL2) and downstream neutrophil
accumulation in the lungs. Epithelial cells from experienced lungs exhibited elevated mRNA …