[HTML][HTML] TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated …
MZ Miranda, JF Bialik, P Speight, Q Dan… - Journal of Biological …, 2017 - ASBMB
Hippo pathway transcriptional coactivators TAZ and YAP and the TGF-β1 (TGFβ) effector
Smad3 regulate a common set of genes, can physically interact, and exhibit multilevel cross-
talk regulating cell fate-determining and fibrogenic pathways. However, a key aspect of this
cross-talk, TGFβ-mediated regulation of TAZ or YAP expression, remains uncharacterized.
Here, we show that TGFβ induces robust TAZ but not YAP protein expression in both
mesenchymal and epithelial cells. TAZ levels, and to a lesser extent YAP levels, also …
Smad3 regulate a common set of genes, can physically interact, and exhibit multilevel cross-
talk regulating cell fate-determining and fibrogenic pathways. However, a key aspect of this
cross-talk, TGFβ-mediated regulation of TAZ or YAP expression, remains uncharacterized.
Here, we show that TGFβ induces robust TAZ but not YAP protein expression in both
mesenchymal and epithelial cells. TAZ levels, and to a lesser extent YAP levels, also …