Interaction of the EGF receptor and the hippo pathway in the diabetic kidney

J Chen, RC Harris - Journal of the American Society of …, 2016 - journals.lww.com
Activation of the EGF receptor (EGFR) or the Hippo signaling pathway can control cell
proliferation, apoptosis, and differentiation, and the dysregulation of these pathways can
contribute to tumorigenesis. Previous studies showed that activation of EGFR signaling in
renal epithelial cells can exacerbate diabetic kidney injury. Moreover, EGFR has been
implicated in regulating the Hippo signaling pathway in Drosophila; thus, we examined this
potential interaction in mammalian diabetic kidney disease. Yes-associated protein (YAP) is …