The transmigration of polymorphonuclear leukocytes (PMNs; neutrophils) into the intestinal
lumen is a classical phenomenon associated with a wide variety of disease states, including
those of both pathogenic and autoimmune/idiopathic origin. While PMNs are highly effective
at killing invading pathogens by releasing microbiocidal products, excessive or unnecessary
release of these substances can cause substantial damage to the intestinal epithelium.
Therefore, it is necessary to understand the underlying mechanisms that lure neutrophils …