The dopamine transporter (DAT) is responsible for the re-uptake of dopamine into
presynaptic nerve terminals and thereby controls dopaminergic neurotransmission. Deletion
of DAT results in a hyperdopaminergic phenotype and DAT−/− mice are characterized by
pituitary hypoplasia, impaired maternal behavior, and increased locomotion. From earlier
studies, we have evidence that the activity of the central dopaminergic system may play a
role in determining immune reactivity and disease susceptibility. To further explore the …