[HTML][HTML] Amphetamine regulation of dopamine transport: Combined measurements of transporter currents and transporter imaging support the endocytosis of an active …
KM Kahlig, JA Javitch, A Galli - Journal of Biological Chemistry, 2004 - ASBMB
Dopaminergic neurotransmission is fine-tuned by the rate of removal of dopamine (DA) from
the extracellular space via the Na+/Cl--dependent DA transporter (DAT). DAT is a target of
psychostimulants such as amphetamine (AMPH) and cocaine. Previously, we reported that
AMPH redistributes the human DAT away from the cell surface. This process was associated
with a reduction in transport capacity. This loss of transport capacity may result either from a
modification of the function of DAT that is independent of its cell surface redistribution and/or …
the extracellular space via the Na+/Cl--dependent DA transporter (DAT). DAT is a target of
psychostimulants such as amphetamine (AMPH) and cocaine. Previously, we reported that
AMPH redistributes the human DAT away from the cell surface. This process was associated
with a reduction in transport capacity. This loss of transport capacity may result either from a
modification of the function of DAT that is independent of its cell surface redistribution and/or …