Oxysterol binding protein like 2 (OSBPL2), an important regulator in cellular lipid metabolism
and transport, was identified as a novel deafness-causal gene in our previous work. To
resemble the phenotypic features of OSBPL2 mutation in animal models and elucidate the
potential genotype-phenotype associations, the OSBPL2-disrupted Bama miniature (BM) pig
model was constructed using CRISPR/Cas9-mediated gene editing, somatic cell nuclear
transfer (SCNT) and embryo transplantation approaches, and then subjected to phenotypic …