A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
CJ Vlahos, WF Matter, KY Hui, RF Brown - Journal of Biological Chemistry, 1994 - ASBMB
Phosphatidylinositol (PtdIns) 3-kinase is an enzyme implicated in growth factor signal
transduction by associating with receptor and nonreceptor tyrosine kinases, including the
platelet-derived growth factor receptor. Inhibitors of PtdIns 3-kinase could potentially give a
better understanding of the function and regulatory mechanisms of the enzyme. Quercetin, a
naturally occurring bioflavinoid, was previously shown to inhibit PtdIns 3-kinase with an IC50
of 1.3 microgram/ml (3.8 microM); inhibition appeared to be directed at the ATP-binding site …
transduction by associating with receptor and nonreceptor tyrosine kinases, including the
platelet-derived growth factor receptor. Inhibitors of PtdIns 3-kinase could potentially give a
better understanding of the function and regulatory mechanisms of the enzyme. Quercetin, a
naturally occurring bioflavinoid, was previously shown to inhibit PtdIns 3-kinase with an IC50
of 1.3 microgram/ml (3.8 microM); inhibition appeared to be directed at the ATP-binding site …