Wnt/β-catenin signaling in T-cell immunity and cancer immunotherapy

L Gattinoni, Y Ji, NP Restifo - Clinical Cancer Research, 2010 - AACR
Clinical Cancer Research, 2010AACR
Wnt ligands are lipid-modified secreted glycoproteins that regulate embryonic development,
cell fate specification, and the homeostasis of self-renewing adult tissues. In addition to its
well-established role in thymocyte development, recent studies have indicated that Wnt/β-
catenin signaling is critical for the differentiation, polarization, and survival of mature T
lymphocytes. Here, we describe our current understanding of Wnt signaling in the biology of
post-thymic T cells, and discuss how harnessing the Wnt/β-catenin pathway might improve …
Abstract
Wnt ligands are lipid-modified secreted glycoproteins that regulate embryonic development, cell fate specification, and the homeostasis of self-renewing adult tissues. In addition to its well-established role in thymocyte development, recent studies have indicated that Wnt/β-catenin signaling is critical for the differentiation, polarization, and survival of mature T lymphocytes. Here, we describe our current understanding of Wnt signaling in the biology of post-thymic T cells, and discuss how harnessing the Wnt/β-catenin pathway might improve the efficacy of vaccines, T-cell–based therapies, and allogeneic stem cell transplantation for the treatment of patients with cancer. Clin Cancer Res; 16(19); 4695–701. ©2010 AACR.
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