[HTML][HTML] Novel dual-color immunohistochemical methods for detecting ERG–PTEN and ERG–SPINK1 status in prostate carcinoma

R Bhalla, LP Kunju, SA Tomlins, K Christopherson… - Modern Pathology, 2013 - Elsevier
Identification of new molecular markers has led to the molecular classification of prostate
cancer based on driving genetic lesions. The translation of these discoveries for clinical use
necessitates the development of simple, reliable and rapid detection systems to screen
patients for specific molecular aberrations. We developed two dual-color
immunohistochemistry-based assays for the simultaneous assessment of ERG–PTEN and
ERG–SPINK1 in prostate cancer. A total of 232 cases from 184 localized and 48 metastatic …