Labeling aversive memory trace in mouse using a doxycycline-inducible expression system

EE Koffman, J Du - Bio-protocol, 2017 - bio-protocol.org
A memory trace, also known as a memory engram, is theorized to be a mechanism for
physical memory storage in the brain (Silva et al., 2009; Josselyn, 2010) and memory trace
is associated with a specific population of neurons (Liu et al., 2012; Ramirez et al., 2013).
Labeling and stimulating those neurons will activate the memory trace (Liu et al., 2012;
Ramirez et al., 2013). Memory appears to be spread over different regions of the brain rather
than being localized to one area. Therefore, the methods used to trace memory have the …