[HTML][HTML] Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration

H Chen, JTA Tran, A Eckerd, TP Huynh, MH Elliott… - Journal of lipid …, 2013 - ASBMB
Light-induced retinal degeneration (LIRD) in albino rats causes apoptotic photoreceptor cell
death. Ceramide is a second messenger for apoptosis. We tested whether increases in
ceramide mediate photoreceptor apoptosis in LIRD and if inhibition of ceramide synthesis
protects the retina. Sprague-Dawley rats were exposed to 2,700 lux white light for 6 h, and
the retinal levels of ceramide and its intermediary metabolites were measured by GC-MS or
electrospray ionization tandem mass spectrometry. Enzymes of the de novo biosynthetic and …