Staphylococcus aureus is a pathogen that often causes severe nosocomial infections
including pneumonia. The present study was designed to examine innate phagocyte
mediated immune mechanisms using a previously described murine S. aureus Newman
pneumonia model. We found that BALB/c mice represent a more susceptible mouse strain
compared to C57BL/6 mice after intranasal S. aureus Newman challenge. Depletion
experiments revealed that neutrophils are a crucial determinant for resistance whereas …