Chronic kidney diseases result from recurrent or progressive injuries in glomeruli, tubules,
interstitium and/or vasculature. To study pathogenesis, mechanisms and effects of
interventions, many animal models have been developed, including spontaneous, genetic
and induced models. However, these models do not exactly simulate human diseases, and
most of them are strain, gender or age dependent. We review key information on various
rodent models of chronic kidney diseases.