CXCR 4, the master regulator of neutrophil trafficking in homeostasis and disease
K De Filippo, SM Rankin - European journal of clinical …, 2018 - Wiley Online Library
European journal of clinical investigation, 2018•Wiley Online Library
Background Chemokines play a critical role in orchestrating the distribution and trafficking of
neutrophils in homeostasis and disease. Results The CXCR 4/CXCL 12 chemokine axis has
been identified as a central regulator of these processes. Conclusion In this review, we focus
on the role of CXCR 4/CXCL 12 chemokine axis in regulating neutrophil release from the
bone marrow and the trafficking of senescent neutrophils back to the bone marrow for
clearance under homeostasis and disease. We also discuss the role of CXCR 4 in fine …
neutrophils in homeostasis and disease. Results The CXCR 4/CXCL 12 chemokine axis has
been identified as a central regulator of these processes. Conclusion In this review, we focus
on the role of CXCR 4/CXCL 12 chemokine axis in regulating neutrophil release from the
bone marrow and the trafficking of senescent neutrophils back to the bone marrow for
clearance under homeostasis and disease. We also discuss the role of CXCR 4 in fine …
Background
Chemokines play a critical role in orchestrating the distribution and trafficking of neutrophils in homeostasis and disease.
Results
The CXCR4/CXCL12 chemokine axis has been identified as a central regulator of these processes.
Conclusion
In this review, we focus on the role of CXCR4/CXCL12 chemokine axis in regulating neutrophil release from the bone marrow and the trafficking of senescent neutrophils back to the bone marrow for clearance under homeostasis and disease. We also discuss the role of CXCR4 in fine‐tuning neutrophil responses in the context of inflammation.
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