[CITATION][C] Macrophage production of TGF‐β and regulation by TGF‐β

SM Wahl, N McCartney‐Francis… - Annals of the New …, 1990 - Wiley Online Library
SM Wahl, N McCartney‐Francis, JB Allen, EB Dougherty, SF Dougherty
Annals of the New York Academy of Sciences, 1990Wiley Online Library
The recruitment and activation of mononuclear phagocytes is central to host defense against
injury, microorganisms, antigens, and neoplasia. Monocytes function not only as scavengers
in clearing debris and other foreign materials, but are also essential as antigen-presenting
accessory cells. In response to lymphokines and other inflammatory mediators, monocytes
subsequently become aggressive effector cells, combatting foreign invaders. In addition to
their contribution to inflammatory events, monocytemacrophages are also instrumental in …
The recruitment and activation of mononuclear phagocytes is central to host defense against injury, microorganisms, antigens, and neoplasia. Monocytes function not only as scavengers in clearing debris and other foreign materials, but are also essential as antigen-presenting accessory cells. In response to lymphokines and other inflammatory mediators, monocytes subsequently become aggressive effector cells, combatting foreign invaders. In addition to their contribution to inflammatory events, monocytemacrophages are also instrumental in mediating the events leading to tissue repair. These cells secrete chemotactic and growth factors that recruit endothelial and mesenchymal cells and promote their synthesis of collagen and other matrix constituents. Because of the contributions of monocyte-macrophages during all phases of the inflammatory and healing response (TABLE I), these cells and their activities continue to be the focus of intense investigation.
The network of cell-cell interactions involved in inflammation and cellular immunity is dependent upon the release of soluble factors or cytokines that may function in an autocrine, paracrine, or endocrine fashion. One of these mediators, recently shown to be produced by monocytes and to interact with many target cells including monocytes themselves, is transforming growth factor-beta (TGF-P). 1-5 Although the initial identification and characterization of TGF-j3 were dependent upon its ability to promote the transformation of nonneoplastic cel1~ P.~ hence its name, TGF-p has numerous other biological activities, many of which may be crucial to the initiation, evolution, and resolution of an inflammatory response.
Wiley Online Library