[HTML][HTML] Immune and inflammatory role in renal disease

JD Imig, MJ Ryan - Comprehensive Physiology, 2013 - ncbi.nlm.nih.gov
JD Imig, MJ Ryan
Comprehensive Physiology, 2013ncbi.nlm.nih.gov
Chronic and acute renal diseases, irrespective of the initiating cause, have inflammation and
immune system activation as a common underlying mechanism. The purpose of this review
is to provide a broad overview of immune cells and inflammatory proteins that contribute to
the pathogenesis of renal disease, and to discuss some of the physiological changes that
occur in the kidney as a result of immune system activation. An overview of common forms of
acute and chronic renal disease is provided, followed by a discussion of common therapies …
Abstract
Chronic and acute renal diseases, irrespective of the initiating cause, have inflammation and immune system activation as a common underlying mechanism. The purpose of this review is to provide a broad overview of immune cells and inflammatory proteins that contribute to the pathogenesis of renal disease, and to discuss some of the physiological changes that occur in the kidney as a result of immune system activation. An overview of common forms of acute and chronic renal disease is provided, followed by a discussion of common therapies that have antiinflammatory or immunosuppressive effects in the treatment of renal disease.
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