Some aldosterone-producing adrenal tumours also secrete cortisol, but present clinically as primary aldosteronism.
TJ Tunny, SA Klemm, RD Gordon - Clinical and Experimental …, 1990 - europepmc.org
TJ Tunny, SA Klemm, RD Gordon
Clinical and Experimental Pharmacology & Physiology, 1990•europepmc.org1. Two patients with angiotensin-responsive aldosterone-producing adenoma (APA) and
one with adrenal cortical carcinoma demonstrated autonomous secretion of cortisol as well
as of aldosterone. 2. The response of cortisol and of aldosterone to ACTH did not
differentiate between the two APA which secreted cortisol and the eight which demonstrated
normal suppression with dexamethasone. 3. Concurrent autonomous secretion of cortisol as
well as aldosterone may occur in patients who present clinically with primary aldosteronism …
one with adrenal cortical carcinoma demonstrated autonomous secretion of cortisol as well
as of aldosterone. 2. The response of cortisol and of aldosterone to ACTH did not
differentiate between the two APA which secreted cortisol and the eight which demonstrated
normal suppression with dexamethasone. 3. Concurrent autonomous secretion of cortisol as
well as aldosterone may occur in patients who present clinically with primary aldosteronism …
1. Two patients with angiotensin-responsive aldosterone-producing adenoma (APA) and one with adrenal cortical carcinoma demonstrated autonomous secretion of cortisol as well as of aldosterone. 2. The response of cortisol and of aldosterone to ACTH did not differentiate between the two APA which secreted cortisol and the eight which demonstrated normal suppression with dexamethasone. 3. Concurrent autonomous secretion of cortisol as well as aldosterone may occur in patients who present clinically with primary aldosteronism. 4. Biochemical distinctions between adenomas may reflect differences in their cellular composition.
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