Background Experimental and human studies demonstrate that long-term exposure to
elevated aldosterone levels results in cardiac and vascular damage. Methods We
investigated long-term cardiovascular outcomes in patients with primary aldosteronism after
surgical or medical treatment. Fifty-four patients with or without evidence of adrenal
adenomas were prospectively followed up for a mean of 7.4 years after treatment with
adrenalectomy or spironolactone. Patients with primary aldosteronism were compared with …