Hypoxic pulmonary vasoconstriction (HPV) is a homeostatic mechanism that is intrinsic to
the pulmonary vasculature. Intrapulmonary arteries constrict in response to alveolar hypoxia,
diverting blood to better-oxygenated lung segments, thereby optimizing ventilation/perfusion
matching and systemic oxygen delivery. In response to alveolar hypoxia, a mitochondrial
sensor dynamically changes reactive oxygen species and redox couples in pulmonary
artery smooth muscle cells (PASMC). This inhibits potassium channels, depolarizes PASMC …