Ablation of type III adenylyl cyclase in mice causes reduced neuronal activity, altered sleep pattern, and depression-like phenotypes
X Chen, J Luo, Y Leng, Y Yang, LS Zweifel… - Biological …, 2016 - Elsevier
Background Although major depressive disorder (MDD) has low heritability, a genome-wide
association study in humans has recently implicated type 3 adenylyl cyclase (AC3; ADCY3)
in MDD. Moreover, the expression level of AC3 in blood has been considered as a MDD
biomarker in humans. Nevertheless, there is a lack of supporting evidence from animal
studies. Methods We employed multiple approaches to experimentally evaluate if AC3 is a
contributing factor for major depression using mouse models lacking the Adcy3 gene …
association study in humans has recently implicated type 3 adenylyl cyclase (AC3; ADCY3)
in MDD. Moreover, the expression level of AC3 in blood has been considered as a MDD
biomarker in humans. Nevertheless, there is a lack of supporting evidence from animal
studies. Methods We employed multiple approaches to experimentally evaluate if AC3 is a
contributing factor for major depression using mouse models lacking the Adcy3 gene …