Amoxapine inhibits the delayed rectifier outward K+ current in mouse cortical neurons via cAMP/protein kinase A pathways
YL He, XQ Zhan, G Yang, J Sun, YA Mei - The Journal of pharmacology …, 2010 - Elsevier
Ion channels are known to be modulated by antidepressant drugs, but the molecular
mechanisms are not known. We have shown that the antidepressant drug amoxapine
suppresses rectifier outward K+(IK) currents in mouse cortical neurons. At a concentration of
10 to 500 μM, amoxapine reversibly inhibited IK in a dose-dependent manner and
modulated both steady-state activation and inactivation properties. The application of
forskolin or dibutyryl cAMP mimicked the inhibitory effect of amoxapine on IK and abolished …
mechanisms are not known. We have shown that the antidepressant drug amoxapine
suppresses rectifier outward K+(IK) currents in mouse cortical neurons. At a concentration of
10 to 500 μM, amoxapine reversibly inhibited IK in a dose-dependent manner and
modulated both steady-state activation and inactivation properties. The application of
forskolin or dibutyryl cAMP mimicked the inhibitory effect of amoxapine on IK and abolished …
