Calmodulin-stimulated adenylyl cyclase gene deletion affects morphine responses
S Li, ML Lee, MR Bruchas, GC Chan, DR Storm… - Molecular …, 2006 - Elsevier
To define the roles of the calmodulin-stimulated adenylyl cyclases (AC1 and AC8) in
morphine-induced analgesia, tolerance, physical dependence, and conditioned place
preference, we used mice having targeted disruptions of either the AC1 or AC8 genes or
both genes [double knockout mice (DKO)]. Mice lacking either AC1 or AC8 genes or DKO
did not differ from wild-type mice in short-term antinociceptive responses to morphine
measured in the tail-flick analgesia assay. Morphine tolerance that developed immediately …
morphine-induced analgesia, tolerance, physical dependence, and conditioned place
preference, we used mice having targeted disruptions of either the AC1 or AC8 genes or
both genes [double knockout mice (DKO)]. Mice lacking either AC1 or AC8 genes or DKO
did not differ from wild-type mice in short-term antinociceptive responses to morphine
measured in the tail-flick analgesia assay. Morphine tolerance that developed immediately …
