Calcium activated adenylyl cyclase AC8 but not AC1 is required for prolonged behavioral anxiety
M Bernabucci, M Zhuo - Molecular Brain, 2016 - Springer
Molecular Brain, 2016•Springer
Background Anxiety disorder is a state of mental discomfort while acute anxiety induces an
enhancement of vigilance/arousal or increased anxious responses. Most of the previous
studies investigated basic mechanisms for acute anxiety, while less information is available
for prolonged or repetitive anxiety. Results In the present study, we wanted to examine
possible molecular mechanisms for behavioral anxiety after repeated exposures. Performing
a paradigm of five sessions of the elevated plus-maze (EPM), we show that the repeated …
enhancement of vigilance/arousal or increased anxious responses. Most of the previous
studies investigated basic mechanisms for acute anxiety, while less information is available
for prolonged or repetitive anxiety. Results In the present study, we wanted to examine
possible molecular mechanisms for behavioral anxiety after repeated exposures. Performing
a paradigm of five sessions of the elevated plus-maze (EPM), we show that the repeated …
Background
Anxiety disorder is a state of mental discomfort while acute anxiety induces an enhancement of vigilance/arousal or increased anxious responses. Most of the previous studies investigated basic mechanisms for acute anxiety, while less information is available for prolonged or repetitive anxiety.
Results
In the present study, we wanted to examine possible molecular mechanisms for behavioral anxiety after repeated exposures. Performing a paradigm of five sessions of the elevated plus-maze (EPM), we show that the repeated exposure to the EPM induces a long-lasting anxiety causing a gradual increase of anxiolytic activity, which is maintained for at least 21 days. Genetic deletion of AC8 (adenylyl cyclase 8) but not AC1 abolished long-lasting anxiety.
Conclusions
Our results suggest that calcium-stimulated AC8 is required to sustain the long-lasting anxiety caused by repeated EPM testing, and we can identify in AC8 a novel target for treating anxiety-related mood disorders.
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