Ca2+ inhibition of type III adenylyl cyclase in vivo (∗)
GA Wayman, S Impey, DR Storm - Journal of Biological Chemistry, 1995 - jbc.org
Type III adenylyl cyclase is stimulated by β-adrenergic agonists and glucagon in vitro and in
vivo, but not by Ca 2+ and calmodulin. However, the enzyme is stimulated by Ca 2+ and
calmodulin in vitro when it is concomitantly activated by the guanyl nucleotide stimulatory
protein G s (Choi, EJ, Xia, Z., and Storm, DR (1992a) Biochemistry 31, 6492-6498). Here, we
examined regulation of type III adenylyl cyclase by G s-coupled receptors and intracellular
Ca 2+ in vivo. Surprisingly, intracellular Ca 2+ inhibited hormone-stimulated type III adenylyl …
vivo, but not by Ca 2+ and calmodulin. However, the enzyme is stimulated by Ca 2+ and
calmodulin in vitro when it is concomitantly activated by the guanyl nucleotide stimulatory
protein G s (Choi, EJ, Xia, Z., and Storm, DR (1992a) Biochemistry 31, 6492-6498). Here, we
examined regulation of type III adenylyl cyclase by G s-coupled receptors and intracellular
Ca 2+ in vivo. Surprisingly, intracellular Ca 2+ inhibited hormone-stimulated type III adenylyl …
