Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies
BACKGROUND: Opiate dependence is a result of adaptive changes in signal transduction
networks in several brain regions. Noradrenergic neurons of the locus coeruleus (LC) have
provided a useful model system in which to understand the molecular basis of these
adaptive changes. One of most robust signaling adaptations to repeated morphine exposure
in this brain region is upregulation of adenylyl cyclase (AC) activity. Earlier work revealed
the selective induction of two calmodulin-dependent AC isoforms, AC1 and AC8, after …
networks in several brain regions. Noradrenergic neurons of the locus coeruleus (LC) have
provided a useful model system in which to understand the molecular basis of these
adaptive changes. One of most robust signaling adaptations to repeated morphine exposure
in this brain region is upregulation of adenylyl cyclase (AC) activity. Earlier work revealed
the selective induction of two calmodulin-dependent AC isoforms, AC1 and AC8, after …
