Functional Co-localization of Transfected Ca2+-stimulable Adenylyl Cyclases with Capacitative Ca2+ Entry Sites (∗)
KA Fagan, R Mahey, DMF Cooper - Journal of Biological Chemistry, 1996 - jbc.org
Three adenylyl cyclases (ACI, ACIII, and ACVIII) have been described, which are putatively
Ca 2+-stimulable, based on in vitro assays. However, it is not clear that these enzymes can
be regulated by physiological rises in [Ca 2+] i when expressed in intact cells. Furthermore,
it is not known whether transfected adenylyl cyclases might display the strict requirement for
capacitative Ca 2+ entry that is shown by the Ca 2+-inhibitable ACVI, which is indigenous to
C6-2B glioma cells (Chiono, M., Mahey, R., Tate, G., and Cooper, DMF (1995) J. Biol. Chem …
Ca 2+-stimulable, based on in vitro assays. However, it is not clear that these enzymes can
be regulated by physiological rises in [Ca 2+] i when expressed in intact cells. Furthermore,
it is not known whether transfected adenylyl cyclases might display the strict requirement for
capacitative Ca 2+ entry that is shown by the Ca 2+-inhibitable ACVI, which is indigenous to
C6-2B glioma cells (Chiono, M., Mahey, R., Tate, G., and Cooper, DMF (1995) J. Biol. Chem …
