[HTML][HTML] Variable BCG efficacy in rhesus populations: Pulmonary BCG provides protection where standard intra-dermal vaccination fails
FAW Verreck, EZ Tchilian, RAW Vervenne… - Tuberculosis, 2017 - Elsevier
M. bovis BCG vaccination against tuberculosis (TB) notoriously displays variable protective
efficacy in different human populations. In non-human primate studies using rhesus
macaques, despite efforts to standardise the model, we have also observed variable efficacy
of BCG upon subsequent experimental M. tuberculosis challenge. In the present head-to-
head study, we establish that the protective efficacy of standard parenteral BCG
immunisation varies among different rhesus cohorts. This provides different dynamic ranges …
efficacy in different human populations. In non-human primate studies using rhesus
macaques, despite efforts to standardise the model, we have also observed variable efficacy
of BCG upon subsequent experimental M. tuberculosis challenge. In the present head-to-
head study, we establish that the protective efficacy of standard parenteral BCG
immunisation varies among different rhesus cohorts. This provides different dynamic ranges …