Discoidin domain receptor 1 null mice are protected against hypertension-induced renal disease
M Flamant, S Placier, A Rodenas… - Journal of the …, 2006 - journals.lww.com
A frequent complication of hypertension is the development of chronic renal failure. This
pathology usually is initiated by inflammatory events and is characterized by the abnormal
accumulation of collagens within the renal tissue. The purpose of this study was to
investigate the role of discoidin domain receptor 1 (DDR1), a nonintegrin collagen receptor
that displays tyrosine-kinase activity, in the development of renal fibrosis. To this end,
hypertension was induced with angiotensin in mice that were genetically deficient of DDR1 …
pathology usually is initiated by inflammatory events and is characterized by the abnormal
accumulation of collagens within the renal tissue. The purpose of this study was to
investigate the role of discoidin domain receptor 1 (DDR1), a nonintegrin collagen receptor
that displays tyrosine-kinase activity, in the development of renal fibrosis. To this end,
hypertension was induced with angiotensin in mice that were genetically deficient of DDR1 …