Ischemia-reperfusion induced acute kidney injury (IR-AKI) is widely used as a model of AKI
in mice, but results are often quite variable with high, often unreported mortality rates that
may confound analyses. Bilateral renal pedicle clamping is commonly used to induce IR-
AKI, but differences between effective clamp pressures and/or renal responses to ischemia
between kidneys often lead to more variable results. In addition, shorter clamp times are
known to induce more variable tubular injury, and while mice undergoing bilateral injury with …