The extracellular matrix receptor discoidin domain receptor 1 regulates collagen transcription by translocating to the nucleus
M Chiusa, W Hu, HJ Liao, Y Su, CM Borza… - Journal of the …, 2019 - journals.lww.com
Background The discoidin domain receptor 1 (DDR1) is activated by collagens, upregulated
in injured and fibrotic kidneys, and contributes to fibrosis by regulating extracellular matrix
production, but how DDR1 controls fibrosis is poorly understood. DDR1 is a receptor
tyrosine kinase (RTK). RTKs can translocate to the nucleus via a nuclear localization
sequence (NLS) present on the receptor itself or a ligand it is bound to. In the nucleus, RTKs
regulate gene expression by binding chromatin directly or by interacting with transcription …
in injured and fibrotic kidneys, and contributes to fibrosis by regulating extracellular matrix
production, but how DDR1 controls fibrosis is poorly understood. DDR1 is a receptor
tyrosine kinase (RTK). RTKs can translocate to the nucleus via a nuclear localization
sequence (NLS) present on the receptor itself or a ligand it is bound to. In the nucleus, RTKs
regulate gene expression by binding chromatin directly or by interacting with transcription …