The role of CD40 and CD154/CD40L in dendritic cells

DY Ma, EA Clark - Seminars in immunology, 2009 - Elsevier
DY Ma, EA Clark
Seminars in immunology, 2009Elsevier
In this review, we focus on the function of CD40–CD40L (CD154) interactions in the
regulation of dendritic cell (DC)–T cell and DC–B cell crosstalk. In addition, we examine
differences and similarities between the CD40 signaling pathway in DCs and other innate
immune cell receptors, and how these pathways integrate DC functions. As research into DC
vaccines and immunotherapies progresses, further understanding of CD40 and DC function
will advance the applicability of DCs in immunotherapy for human diseases.
In this review, we focus on the function of CD40–CD40L (CD154) interactions in the regulation of dendritic cell (DC)–T cell and DC–B cell crosstalk. In addition, we examine differences and similarities between the CD40 signaling pathway in DCs and other innate immune cell receptors, and how these pathways integrate DC functions. As research into DC vaccines and immunotherapies progresses, further understanding of CD40 and DC function will advance the applicability of DCs in immunotherapy for human diseases.
Elsevier