Precision cancer immunotherapy: optimizing dendritic cell-based strategies to induce tumor antigen-specific T-cell responses against individual patient tumors
T Osada, K Nagaoka, M Takahara… - Journal of …, 2015 - journals.lww.com
Most dendritic cell (DC)-based vaccines have loaded the DC with defined antigens, but
loading with autologos tumor-derived antigens would generate DCs that activate
personalized tumor-specific T-cell responses. We hypothesized that DC matured with an
optimized combination of reagents and loaded with tumor-derived antigens using a clinically
feasible electroporation strategy would induce potent antitumor immunity. We first studied
the effects on DC maturation and antigen presentation of the addition of picibanil (OK432) to …
loading with autologos tumor-derived antigens would generate DCs that activate
personalized tumor-specific T-cell responses. We hypothesized that DC matured with an
optimized combination of reagents and loaded with tumor-derived antigens using a clinically
feasible electroporation strategy would induce potent antitumor immunity. We first studied
the effects on DC maturation and antigen presentation of the addition of picibanil (OK432) to …