Pericyte abnormalities precede strial capillary basement membrane thickening in Alport mice
B Dufek, DT Meehan, D Delimont, G Samuelson… - Hearing research, 2020 - Elsevier
Abstract In 129 Sv autosomal Alport mice, the strial capillary basement membranes (SCBMs)
progressively thicken between 5 and 9 weeks of age resulting in a hypoxic
microenvironment with metabolic stress and induction of pro-inflammatory cytokines and
chemokines. These events occur concomitant with a drop in endocochlear potential and a
susceptibility to noise-induced hearing loss under conditions that do not permanently affect
age/strain-matched littermates. Here we aimed to gain an understanding of events that occur …
progressively thicken between 5 and 9 weeks of age resulting in a hypoxic
microenvironment with metabolic stress and induction of pro-inflammatory cytokines and
chemokines. These events occur concomitant with a drop in endocochlear potential and a
susceptibility to noise-induced hearing loss under conditions that do not permanently affect
age/strain-matched littermates. Here we aimed to gain an understanding of events that occur …