[HTML][HTML] Protective effect of the immunosuppressant sirolimus against aortic atherosclerosis in apo E-deficient mice

MM Elloso, N Azrolan, SN Sehgal, PL Hsu… - American Journal of …, 2003 - Elsevier
Atherosclerosis is a chronic inflammatory disease that develops in response to injury to the
vessel wall, and is augmented by hypercholesterolemia. To further delineate the role of the
immune system and local factors in this process, we assessed the effects of the
immunosuppressant sirolimus (Rapamycin, RAPAMUNEŽ, Wyeth, Collegeville, PA) on
atherosclerosis in the apoE-deficient (apoE KO) mouse, a well-accepted model of
cardiovascular disease. ApoE KO mice were fed a high fat diet and sirolimus was …