Inadequate reinforcement of transmedial disruptions at branch points subtends aortic aneurysm formation in apolipoprotein-E-deficient mice
Introduction Infusion of angiotensin-II (Ang-II) in apolipoprotein-E-deficient mice (Apo-E-/-)
results in suprarenal abdominal aortic aneurysm (AAA) in 30–85% of cases. This study
identifies the apparent mechanism by which some animals do, but others do not, develop
AAA in this model. Methods Male Apo-E-/-mice were infused with Ang-II (n= 21) or saline (n=
6) and sacrificed at 4 weeks. Aortas were excised, embedded in paraffin, sectioned (250 μm
intervals), and stained. Sites of transmedial disruption (TMD) were identified and …
results in suprarenal abdominal aortic aneurysm (AAA) in 30–85% of cases. This study
identifies the apparent mechanism by which some animals do, but others do not, develop
AAA in this model. Methods Male Apo-E-/-mice were infused with Ang-II (n= 21) or saline (n=
6) and sacrificed at 4 weeks. Aortas were excised, embedded in paraffin, sectioned (250 μm
intervals), and stained. Sites of transmedial disruption (TMD) were identified and …