We report here on the early pathology of a well-established murine model of dissecting
abdominal aortic aneurysms (AAAs). Continuous infusion of angiotensin II (AngII) into
apolipoprotein E-deficient mice induces the formation of aortic dissection and expansion at
some point after implantation of miniosmotic pumps containing AngII. While this model has
been studied extensively at a chronic stage, we investigated the early pathology of
dissecting AAA formation at multiple scales. Using high-frequency ultrasound, we screened …