A short field guide to fibroblast function in immunity

MB Buechler, SJ Turley - Seminars in immunology, 2018 - Elsevier
Seminars in immunology, 2018Elsevier
Fibroblasts in secondary lymphoid organs, or fibroblastic reticular cells (FRC), are gate-
keepers of immune responses. Here, we frame how these cells regulate immune responses
via a three-part scheme in which FRC can setup, support or suppress immune responses.
We also review how fibroblasts from non-lymphoid tissues influence immunity and highlight
how they resemble and differ from FRC. Overall, we aim to focus attention on the emerging
roles of lymphoid tissue and non-lymphoid tissue fibroblasts in control of innate and …
Abstract
Fibroblasts in secondary lymphoid organs, or fibroblastic reticular cells (FRC), are gate-keepers of immune responses. Here, we frame how these cells regulate immune responses via a three-part scheme in which FRC can setup, support or suppress immune responses. We also review how fibroblasts from non-lymphoid tissues influence immunity and highlight how they resemble and differ from FRC. Overall, we aim to focus attention on the emerging roles of lymphoid tissue and non-lymphoid tissue fibroblasts in control of innate and adaptive immunity.
Elsevier