IL-17A augments TNF-α–induced IL-6 expression in airway smooth muscle by enhancing mRNA stability
S Henness, CK Johnson, Q Ge, CL Armour… - Journal of Allergy and …, 2004 - Elsevier
BACKGROUND: IL-17A is implicated in the regulation of inflammation and is found in
increased amounts in the asthmatic airway. Human airway smooth muscle (ASM) cells
synthesize cell adhesion molecules and cytokines in response to inflammatory mediators.
OBJECTIVE: In this study, we examined whether IL-17A modulated the synthetic function of
ASM cells. METHODS: Primary ASM cultures were treated with IL-17A alone and in
combination with the proinflammatory cytokines TNF-α and IL-1β. Intercellular adhesion …
increased amounts in the asthmatic airway. Human airway smooth muscle (ASM) cells
synthesize cell adhesion molecules and cytokines in response to inflammatory mediators.
OBJECTIVE: In this study, we examined whether IL-17A modulated the synthetic function of
ASM cells. METHODS: Primary ASM cultures were treated with IL-17A alone and in
combination with the proinflammatory cytokines TNF-α and IL-1β. Intercellular adhesion …