[HTML][HTML] Periductal stromal collagen topology of pancreatic ductal adenocarcinoma differs from that of normal and chronic pancreatitis

CR Drifka, J Tod, AG Loeffler, Y Liu, GJ Thomas… - Modern Pathology, 2015 - Elsevier
Pancreatic ductal adenocarcinoma continues to be one of the most difficult diseases to
manage with one of the highest cancer mortality rates. This is due to several factors
including nonspecific symptomatology and subsequent diagnosis at an advanced stage,
aggressive metastatic behavior that is incompletely understood, and limited response to
current therapeutic regimens. As in other cancers, there is great interest in studying the role
of the tumor microenvironment in pancreatic ductal adenocarcinoma and whether …